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Dear Sir, We have read the article by Patra[ 1 ] et al. Arthanari, M. S, for his logistic support. Successful intervention in a child with toxic methemoglobinemia due to nail polish remover poisoning. Acute acetone intoxication in a pediatric patient. The body can make energy in several ways.
The first is by turning food substances such as carbohydrates into glucose. But if a person is not eating many carbohydrates, the body cannot use dietary glucose for energy. Instead, it switches to glucose that was converted and stored for energy reserves, including within fat.
If this occurs, the liver will begin breaking down fat reserves. In the process of doing this, the body makes ketones as a byproduct. Acetone is a type of ketone. Once the body begins producing excess ketones, this state is known as ketosis. Being in ketosis can be safe or even beneficial for some people. For example, the ketogenic keto diet deliberately induces a state of ketosis. There is evidence this can reduce seizures in children with epilepsy , and research into potential benefits for other conditions is ongoing.
But having too many ketones is dangerous, especially for people with diabetes mellitus. This may lead to diabetic ketoacidosis DKA , a serious complication that can cause a diabetic coma or death. It has a low potential for causing acute or chronic health problems. But it does have some risks. Acetone liquid and vapor catch fire easily.
People should never use acetone-based products around an open flame or while smoking. Acetone is an irritant, which means it can irritate the skin. For this reason, some people cannot use acetone-based nail polish removers. If a person is exposed to or inhales acetone fumes, it may also irritate the eyes, nose, throat, or lungs. This can cause :.
Severe exposure to acetone vapor may cause damage to the nervous system, confusion, or unconsciousness. Typically , ingesting a small amount of acetone will not harm an otherwise healthy person. Certain amounts could harm a child, and adults who ingest a large amount of acetone may be at risk for acetone poisoning.
Sounds serious! That was the list of effects for ethanol. Here are the effects for acetone :. Ingestion: May cause irritation of the digestive tract. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. For ethanol it is around 7. For better or worse, food manufacturers can put acetone in food and sell it to you without testing for safety. This seems to be common with spice oleoresins concentrated forms of spices. In a thread on bluelight , Psychedelic Jay reports:.
So far 1 ml of pure acetone in 10 ml of water. Effects: Slight sedation, easy going sense of euphoria, very similar but smoother than ethanol intoxication. Heart rate increased by beats a minute… Blood pressure exactly the same…. Acta Pharmacol. Cited in Morgott, Krasavage, W. O'Donoghue and G. In: Patty's Industrial Hygiene and Toxicology , 3rd rev. Clayton and F. Clayton, eds. Wiley Interscience, New York. Kumai, M. Koizumi, K. Saito, et al. A nationwide survey on organic solvent components in various solvent products: Part 2.
Heterogeneous products such as paints, inks, and adhesives. Health Ladefoged, O. Hass and L. Neurophysiological and behavioral effects of combined exposure to 2,5-hexanedione and acetone or ethanol in rats. Lykkegaard and O. Infertility in rats induced by 2,4-hexanedione in combination with acetone. Mast, T. Evanoff, R. Rommereim, et al. Cited in Morgott, Mashbitz, L. Sklianskaya and F. The relative toxicity of acetone, methylalcohol and their mixtures: II. Their action on white mice.
Yoshimune, A. Inoue, et al. Experimental studies for determining the MAC value of acetone. Biological reaction time in the "one-day exposure" to acetone. Sangyo Igaku Goshima, H. Miyagaki, et al. Biological reaction time in the "six-day exposure" to acetone. Marliac, M. Verrett, et al. Toxicity of fourteen volatile chemicals as measured by the chick embryo method. Cited in Morgott, Misumi, J. Neurophysiological studies on the relation between the structural properties and neurotoxicity of aliphatic hydrocarbon compounds in rats.
Cited in Morgott, Mizunuma, K. Yasugi, T. Kawai, et al. Exposure-excretion relationship of styrene and acetone in factory workers: a comparison of a lipophilic solvent and a hydrophilic solvent. Morgott, D. In: Patty's Industrial Hygiene and Toxicology , 4th ed. Ege, Jr. Ross, et al. Sensory response to certain industrial solvent vapors. Hygiene Toxicol. Oglesby, F. Williams and D. Eighteen-year experience with aceton.
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Cited in Morgott, Pozzani, U. Weil and C. The toxicological basis for threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data.
Cited in Morgott, Raleigh, R. Effects of short, high-concentration exposures to acetone as determined by observation in the work area. Petrali and V. Cataracts induced in guinea pigs by acetone, cyclohexanone, and dimethyl sulfoxide. Optom Physiol. Optics Attempt to induce cataracts induced in rabbits by cutaneous application of acetone.
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