You may need urgent medical care. You may also contact the poison control center at Headache, weight loss, dry mouth, trouble sleeping insomnia , nausea, dizziness, constipation, fast heartbeat, and sore throat. These will often improve over the first week or two as you continue to take the medication. Unlike many antidepressants, bupropion does not commonly cause sexual side effects and may be selected as an alternative treatment when antidepressant-induced sexual side effects are problematic.
Sexual side effects include such problems as difficulty achieving orgasm or ejaculatory delay. In general the risk of seizures due to bupropion is low. The risk of having a seizure increases with higher than recommended doses of bupropion, a history of seizures or head injury, tumor in the brain, severe liver disease, an eating disorder, alcohol or drug dependence, or taking other drugs that can also increase your risk of having a seizure.
There is a low risk of cardiovascular adverse events associated with stimulating agents, including bupropion. This risk increases if you have heart disease, high blood pressure, previous heart attack, or irregular heartbeat, or when used with transdermal nicotine replacement products.
In these cases, a thorough cardiovascular evaluation is recommended before starting this medicine. To date, there are no known problems associated with long term use of bupropion. It is a safe and effective medication when used as directed. Bupropion should not be taken with or within two weeks of taking monoamine oxidase inhibitors MAOIs.
There are several products with the active ingredient bupropion. Do not take more than one product that contains bupropion since this may increase your risk of having a seizure. Certain medications may increase your risk of having a seizure when combined with bupropion. These include other antidepressants, antipsychotics, theophylline, isoniazid, tramadol, stimulants, steroids, hypoglycemic agents including insulin , certain antibiotics e.
These medications can change the way your body reacts to bupropion. Bupropion can change the way your body reacts to these medications. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in actiities may need up to weeks to fully improve.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age Adults ages 65 and older taking antidepressants have a decreased risk of suicidality.
Patients, their families and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
Last Updated: January This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. This information is for educational and informational purposes only and is not medical advice. This information contains a summary of important points and is not an exhaustive review of information about the medication. Always seek the advice of a physician or other qualified medical professional with any questions you may have regarding medications or medical conditions.
Never delay seeking professional medical advice or disregard medical professional advice as a result of any information provided herein. The College of Psychiatric and Neurologic Pharmacists disclaims any and all liability alleged as a result of the information provided herein. Search Close Menu. Sign In About Mental Illness. About Mental Illness Treatments. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:.
This medication should not be used if you are suddenly stopping regular use of sedatives including benzodiazepines such as lorazepam , drugs used to treat seizures, or alcohol. Doing so may increase your risk of seizures. This drug may make you dizzy. Alcohol or marijuana cannabis can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
Avoid alcoholic beverages. Talk to your doctor if you are using marijuana cannabis. Alcohol can also increase your risk of seizures.
Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Older adults may be more sensitive to the side effects of this drug, especially dizziness and memory loss. Dizziness can increase the risk of falling. During pregnancy, this medication should be used only when clearly needed. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.
This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction.
Avoid taking MAO inhibitors isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication.
Ask your doctor when to start or stop taking this medication. Tell laboratory personnel and all your doctors you use this drug. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call Otherwise, call a poison control center right away.
US residents can call their local poison control center at Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures, severe confusion, hallucinations, rapid heart rate, loss of consciousness. Keep all regular medical and psychiatric appointments.
Consult your doctor for more details. If you miss a dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. Store at room temperature away from light and moisture. Do not store in the bathroom. If you drink alcohol, talk with your doctor about whether this drug is safe for you. For people with a seizure disorder: This drug raises the risk of seizures. You should not take this drug if you have a seizure disorder.
For people with eating disorders such as bulimia or anorexia: This drug raises your risk for seizures. You should not take this drug if you have an eating disorder. For people with bipolar disorder: This drug may make your condition worse. You should not take this drug if you have bipolar disorder.
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. Your doctor may reduce your dosage of this drug, or how often you are given this drug.
For people with liver disease: Your doctor may reduce your dosage of this drug, or how often you are given this drug. For people with angle-closure glaucoma: This drug can make your condition worse. For pregnant women: This drug is a category C pregnancy drug. That means two things:. This drug should only be used if the potential benefit justifies the potential risk. For women who are breastfeeding: This drug passes into breast milk and may cause side effects in a child who is breastfed.
Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. For seniors: The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time.
This raises your risk for side effects. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:. It has not been confirmed that this drug is safe and effective for use in people younger than 18 years. The kidneys of older adults may not work as well as they used to.
This raises your risk of side effects. Treatment with this drug should start before you plan to quit smoking. You should set a target quit date within the first 2 weeks of treatment with this drug. Treatment should be continued for 7—12 weeks. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages.
Always speak with your doctor or pharmacist about dosages that are right for you. Bupropion oral tablet is used for long-term treatment of depression or SAD. Or you may not be able to quit smoking. For this drug to work well, a certain amount needs to be in your body at all times. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:. If your symptoms are severe, call or go to the nearest emergency room right away.
What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose.
Never try to catch up by taking two doses at once. This could result in dangerous side effects. How to tell if the drug is working: Your symptoms of depression or SAD should decrease. Or you may be able to quit smoking. A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled.
Your doctor will write the number of refills authorized on your prescription. You and your doctor should monitor certain health issues.
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